Research shows, that carrying a few extra pounds increases the likelihood of developing osteoarthritis, as excessive fat levels are associated with underlying hormonal issues. Neither genetic predisposition or a beer belly, can cause our joints to become arthritic, in the absence of hormonal issue, hiding beneath the surface.
Whilst being overweight and having the genes to develop either osteoarthritis (or diabetes), are factors in the development of osteoarthritis.
Being born with the genes and being overweight, does not mean that the condition will develop, unless lifestyle related factors were to trigger this. It is only when the genes are triggered into action, that osteoarthritis will develop.
Some of the biggest triggers to develop osteoarthritis are hormonal health issues. As our hormonal health impacts the health of our joints (Courties, 2017). So when we have a hormonal imbalance, it predisposes us to develop multiple metabolic conditions, including Osteoarthritis (Kluzek, 2015). One researcher describes this connection between hormonal issues and joint issues when he wrote:
"OA (osteoarthritis) should not be thought of as a single disease, but rather as the clinical endpoint of numerous disorders leading to the eventual failure of one or more joints of the body" (Sokolove, 2013)
Like Diabetes, osteoarthritis is a metabolic condition (Kluzek, 2015) that is lifestyle related, that can be controlled. The research is clearly optimistic as it shows that osteoarthritis, like Diabetes is a condition that can be managed because it is lifestyle related!
Many "modern" metabolic conditions, which impair the internal functions of our organs, are associated with insulin resistance. This is where tissue within the body no longer opens up to the doors, to allow sugar and protein to come in, because the hormonal key:
Insulin - to unlock the door has been overused.
Having unmanaged insulin resistance, results in an excessive amount of sugar floating around in the bloodstream, because none of the doors will open up.
Eventually this free floating sugar binds with another free floating fat or protein, in a process called Glycation. Where the fat/protein and sugar becomes Glycated together, within the bloodstream. Glycated products enter into our joints (Foitschik, 2005), which predisposes our joints to become arthritic and restricted (DeGroot, 2004), (Ozawa,2017).
This process is similar to Gout where, poor protein management, leads to protein crystals forming within a joint, especially the big toe. Leading to a cascade of effects within the joint:
A- Cellular damage, of the cartilage, which leads to cellular debris getting trapped within the joint.
B- Setting off the inflammatory response
C- Through stagnation of fluids, lubricating synovial fluid turn into viscous fluid gel, that leads to friction and irritation within the joint.
The difference between Glycation of our joints and protein crystal formation, is that glycation doesn't happen overnight. Glycation formation within a joint creates a dull ache, wheras gout gives acute sharp pain.